Vaccination with Trichinella spirallis antigens increases CD8+ peripheral T cells and enhances the Th2 immune response in Leishmania infantum challenged mice.
Τίτλος | Vaccination with Trichinella spirallis antigens increases CD8+ peripheral T cells and enhances the Th2 immune response in Leishmania infantum challenged mice. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Daoudaki, M., Diakou A., Frydas S., Fouzas I., Karagouni E., Vavatsi N., & Haralabidis S. |
Journal | Int J Immunopathol Pharmacol |
Volume | 22 |
Issue | 1 |
Pagination | 169-74 |
Date Published | 2009 Jan-Mar |
ISSN | 0394-6320 |
Λέξεις κλειδιά | Animals, Antibodies, Protozoan, Antigens, Helminth, CD8-Positive T-Lymphocytes, Female, Immunoglobulin G, Leishmania infantum, Leishmaniasis, Visceral, Mice, Mice, Inbred BALB C, Th2 Cells, Trichinella spiralis, Vaccination |
Abstract | In this study we investigate the effect of Trichinella spiralis vaccination on immune responses elicited in BALB/c mice challenged subcutaneously with 0.5 x 10 6 of Leishmania infantum promastigotes. Secretion of specific anti-L. infantum antibodies and changes in the number of CD4+, CD8+ T cell and CD19+ B cells in the peripheral blood were tested for the evaluation of immune responses. Immunization with low amounts of T. spiralis antigens induced depression in anti-Leishmania specific antibodies of the IgG1 isotype, while no changes in the number of CD4+ and CD8+ T cell subpopulations or CD19+ B cells were observed. In contrast, high amounts of T. spiralis antigens induced an enhancement in anti-Leishmania specific antibodies of total IgG and IgG1 isotype, increase of CD8+ T cell number and activation of CD19+ B cells, indicated by the co-expression of CD69 marker. Our results suggest that immunization with a certain dose of T. spiralis antigens in experimentally challenged mice with L. infantum leads to an increase of peripheral CD8+ T cells which are responsible for the control of L. infantum infection, although a simultaneous enhancement in Th2-type of immune response is also observed. |
Alternate Journal | Int J Immunopathol Pharmacol |
PubMed ID | 19309564 |