Δημοσίευση

Vascular calcification: the role of microRNAs.

ΤίτλοςVascular calcification: the role of microRNAs.
Publication TypeJournal Article
Year of Publication2017
AuthorsAlkagiet, S., & Tziomalos K.
JournalBiomol Concepts
Volume8
Issue2
Pagination119-123
Date Published2017 May 24
ISSN1868-503X
Λέξεις κλειδιάHumans, MicroRNAs, Signal Transduction, Vascular Calcification
Abstract

Vascular calcification represents the deposition of calcium phosphate salts in the tunica media of the vascular wall. It occurs during aging but is accelerated and pronounced in patients with diabetes mellitus, chronic kidney disease (CKD) and established cardiovascular disease. Due to the loss of elasticity of the vessel wall, vascular calcification might result in left ventricular hypertrophy and compromise coronary perfusion. Accordingly, several studies showed that vascular calcification is associated with increased risk for cardiovascular morbidity and mortality. Accumulating data suggest that microRNAs (miRs) play an important role in vascular calcification. A variety of miRs have been implicated in the development of vascular calcification, whereas others appear to play a protective role. Accordingly, miRs might represent promising targets for the prevention of vascular calcification and its adverse cardiovascular sequelae. However, given the complexity of regulation of this process and the multitude of miRs involved, more research is needed to identify the optimal candidate miRs for targeting.

DOI10.1515/bmc-2017-0001
Alternate JournalBiomol Concepts
PubMed ID28426428

Επικοινωνία

Τμήμα Ιατρικής, Πανεπιστημιούπολη ΑΠΘ, T.K. 54124, Θεσσαλονίκη
 

Συνδεθείτε

Το τμήμα Ιατρικής στα κοινωνικά δίκτυα.
Ακολουθήστε μας ή συνδεθείτε μαζί μας.