Vitamin D receptor activators and response to injury in kidney diseases.
Τίτλος | Vitamin D receptor activators and response to injury in kidney diseases. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Eleftheriadis, T., Antoniadi G., Liakopoulos V., Antoniadis N., Stefanidis I., & Galaktidou G. |
Journal | J Nephrol |
Volume | 23 |
Issue | 5 |
Pagination | 514-24 |
Date Published | 2010 Sep-Oct |
ISSN | 1121-8428 |
Λέξεις κλειδιά | Animals, Humans, Immunologic Factors, Kidney Diseases, Receptors, Calcitriol, Renal Dialysis |
Abstract | Clinical studies have confirmed that administration of vitamin D receptor (VDR) activators offers a survival benefit in hemodialysis patients and may help in preservation of renal function in predialysis patients. Accumulated clinical and mainly experimental data support that in the context of kidney disease, VDR activators exert their beneficial effect not only due to their action on calcium and phosphorus homeostasis, but also through modulation of the response to injury. They attenuate systemic and renal inflammation, and they affect the tissue repair process, reducing renal fibrosis. This aspect of the functions of VDR activators in kidney disease is reviewed in the present manuscript. |
Alternate Journal | J. Nephrol. |
PubMed ID | 20540037 |