Association of the CETP Taq1B and LIPG Thr111Ile Polymorphisms with Glycated Hemoglobin and Blood Lipids in Newly Diagnosed Hyperlipidemic Patients.
Title | Association of the CETP Taq1B and LIPG Thr111Ile Polymorphisms with Glycated Hemoglobin and Blood Lipids in Newly Diagnosed Hyperlipidemic Patients. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Agapakis, D., Savopoulos C., Kypreos K. E., Gbandi E., Iliadis S., Hatzitolios A. I., & Goulas A. |
Journal | Can J Diabetes |
Volume | 40 |
Issue | 6 |
Pagination | 515-520 |
Date Published | 2016 Dec |
ISSN | 2352-3840 |
Keywords | Adult, Biomarkers, Cholesterol Ester Transfer Proteins, Female, Follow-Up Studies, Glycated Hemoglobin A, Humans, Hyperlipidemias, Lipase, Lipids, Male, Middle Aged, Polymorphism, Genetic, Prognosis, Retrospective Studies, Taq Polymerase |
Abstract | OBJECTIVE: To examine the association of 2 common polymorphisms in high-density lipoprotein (HDL)-related genes, namely, cholesterol ester transfer protein CETP Taq1B (rs708272) and endothelial lipase LIPG Thr111Ile (rs2000813), with glycated hemoglobin (A1C), blood lipid levels and the risk for type 2 diabetes in a group of hyperlipidemic patients from northern Greece.METHODS: We categorized 175 patients with hyperlipidemia into 2 subgroups according to the presence or absence of type 2 diabetes, defined as a recent diagnosis, A1C >6.5% and/or fasting glucose >126 mg/dL. Genotypes for the 2 polymorphisms studied were determined by polymerase chain reaction-restriction fragment length polymorphism. Both polymorphisms were analyzed by multivariate and univariate analyses of baseline A1C levels and plasma lipids. The genotype and allele frequencies of the 2 subgroups were compared.RESULTS: The CETP Taq1B polymorphism was associated with HDL-cholesterol (HDL-C) and A1C levels, but this association was affected by type 2 diabetes; the association with A1C levels was significant only in type 2 diabetes (p=0.005), whereas the association with HDL-C occurred only in the subgroup without type 2 diabetes (p<0.001). LIPG Thr111Ile did not affect plasma HDL-C or A1C levels independently but appeared to modulate their association with CETP Taq1B, and LIPG 111IleIle homozygotes tended to be present at a higher frequency in the hyperlipidemic patients with type 2 diabetes compared to the hyperlipidemic patients without type 2 diabetes (p=0.056).CONCLUSIONS: In hyperlipidemic patients, apart from its known association with HDL-C, CETP Taq1B is also associated with A1C levels, and both associations are modified by type 2 diabetes and LIPG Thr111Ile. |
DOI | 10.1016/j.jcjd.2016.01.002 |
Alternate Journal | Can J Diabetes |
PubMed ID | 27590083 |