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Evaluation of Cerebral Oxygenation in Neonates with Sepsis with Near-Infrared Spectroscopy.

TitleEvaluation of Cerebral Oxygenation in Neonates with Sepsis with Near-Infrared Spectroscopy.
Publication TypeJournal Article
Year of Publication2017
AuthorsRallis, D., Karagianni P., Milona E., Pratsiou P., Nikolaidis N., & Tsakalidis C.
JournalAm J Perinatol
Volume34
Issue5
Pagination419-427
Date Published2017 04
ISSN1098-8785
KeywordsCase-Control Studies, Cerebrum, Female, Humans, Infant, Newborn, Male, Oxygen, Prospective Studies, Sepsis, Severity of Illness Index, Shock, Septic, Spectroscopy, Near-Infrared, Time Factors
Abstract

 Neonates with sepsis have increased risk of cerebral injury. Our aim was to evaluate cerebral oxygenation in septic neonates using near-infrared spectroscopy.  A prospective study was designed enrolling neonates with sepsis, as defined by the International Consensus Conference of Pediatric Sepsis criteria and matched controls. Three cerebral half-hourly measurements were performed during the first, third, and seventh day of the episode and the values of tissue oxygenation index (TOI) and fractional tissue oxygen extraction (FTOE) were compared between the two groups.  The study population consisted of 50 septic and 44 control neonates with similar characteristics. No differences on TOI and FTOE were recorded in the first and third day. However, on the seventh day, septic neonates had significantly decreased oxygenation (62.7 ± 7 vs. 71.4 ± 4.4%,  < 0.001) and increased oxygen extraction (0.35 ± 0.07 vs. 0.27 ± 0.05,  < 0.001), irrespectively of the severity of the infection.  Although septic neonates have normal cerebral oxygenation in the first and third day of the sepsis, they present decreased cerebral oxygenation in the seventh day independently of the infection severity.

DOI10.1055/s-0036-1592348
Alternate JournalAm J Perinatol
PubMed ID27627794

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