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Vitamin D and diabetes mellitus: Causal or casual association?

TitleVitamin D and diabetes mellitus: Causal or casual association?
Publication TypeJournal Article
Year of Publication2017
AuthorsGrammatiki, M., Rapti E., Karras S., Ajjan R. A., & Kotsa K.
JournalRev Endocr Metab Disord
Volume18
Issue2
Pagination227-241
Date Published2017 06
ISSN1573-2606
KeywordsAnimals, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Insulin-Secreting Cells, Risk Factors, Vitamin D, Vitamin D Deficiency
Abstract

The incidence of both type 2 and type 1 diabetes mellitus has been increasing worldwide. Vitamin D deficiency, or the awareness of its prevalence, has also been increasing. Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic β-cell function. Vitamin D status or elements involved in its activation or transport may also be involved in the development of type 1 diabetes mellitus through immunomodulatory role . Based on these observations a potential association between vitamin D and diabetes has been hypothesized. In this review we discuss up to date evidence linking vitamin D with the development of diabetes. Moreover, the role of vitamin D supplementation in the prevention of both types of diabetes is analysed together with its role in improving glycemic control in diabetic patients. We also address the potential role of vitamin D deficiency in the development of macro- and microvascular complications in diabetes. Finally, we provide recommendation for Vitamin D therapy in diabetes in view of current evidence and highlight areas for potential future research in this area.

DOI10.1007/s11154-016-9403-y
Alternate JournalRev Endocr Metab Disord
PubMed ID28062940

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