Vitamin D and diabetes mellitus: Causal or casual association?
Title | Vitamin D and diabetes mellitus: Causal or casual association? |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Grammatiki, M., Rapti E., Karras S., Ajjan R. A., & Kotsa K. |
Journal | Rev Endocr Metab Disord |
Volume | 18 |
Issue | 2 |
Pagination | 227-241 |
Date Published | 2017 06 |
ISSN | 1573-2606 |
Keywords | Animals, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Insulin-Secreting Cells, Risk Factors, Vitamin D, Vitamin D Deficiency |
Abstract | The incidence of both type 2 and type 1 diabetes mellitus has been increasing worldwide. Vitamin D deficiency, or the awareness of its prevalence, has also been increasing. Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic β-cell function. Vitamin D status or elements involved in its activation or transport may also be involved in the development of type 1 diabetes mellitus through immunomodulatory role . Based on these observations a potential association between vitamin D and diabetes has been hypothesized. In this review we discuss up to date evidence linking vitamin D with the development of diabetes. Moreover, the role of vitamin D supplementation in the prevention of both types of diabetes is analysed together with its role in improving glycemic control in diabetic patients. We also address the potential role of vitamin D deficiency in the development of macro- and microvascular complications in diabetes. Finally, we provide recommendation for Vitamin D therapy in diabetes in view of current evidence and highlight areas for potential future research in this area. |
DOI | 10.1007/s11154-016-9403-y |
Alternate Journal | Rev Endocr Metab Disord |
PubMed ID | 28062940 |