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Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor.

TitleCongenital Glioblastoma Multiforme: An Unusual and Challenging Tumor.
Publication TypeJournal Article
Year of Publication2017
AuthorsAnestis, D. M., Tsitsopoulos P. P., Ble C. A., Tsitouras V., & Tsonidis C. A.
JournalNeuropediatrics
Volume48
Issue6
Pagination403-412
Date Published2017 Dec
ISSN1439-1899
KeywordsCentral Nervous System Neoplasms, Glioblastoma, Humans
Abstract

Congenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.

DOI10.1055/s-0037-1601858
Alternate JournalNeuropediatrics
PubMed ID28399590

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