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Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer.

TitleProgesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer.
Publication TypeJournal Article
Year of Publication2009
AuthorsPapanikolaou, E. G., Kolibianakis E. M., Pozzobon C., Tank P., Tournaye H., Bourgain C., Van Steirteghem A., & Devroey P.
JournalFertil Steril
Volume91
Issue3
Pagination949-52
Date Published2009 Mar
ISSN1556-5653
KeywordsAdult, Chorionic Gonadotropin, Drug Therapy, Combination, Embryo Implantation, Embryo Transfer, Female, Fertility Agents, Female, Follicle Stimulating Hormone, Gonadotropin-Releasing Hormone, Hormone Antagonists, Humans, Luteal Phase, Ovulation Induction, Pregnancy, Pregnancy Outcome, Progesterone, Prospective Studies, Recombinant Proteins, Time Factors, Up-Regulation
Abstract

Four hundred eighty-two patients undergoing single ET with GnRH-antagonist/recFSH protocol were analyzed. The incidence of premature luteinization (P above 1.5 ng/mL on the day of hCG administration) was 18.2%. Even modest rises of P in the follicular phase have detrimental effect on the implantation potential of a good-quality cleavage stage embryo. On the contrary, premature luteinization in the blastocyst subgroup had no effect on the pregnancy outcome.

DOI10.1016/j.fertnstert.2006.12.064
Alternate JournalFertil. Steril.
PubMed ID17555751

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