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Variable skeletal anatomical features of acromegaly in the skull and craniocervical junction.

TitleVariable skeletal anatomical features of acromegaly in the skull and craniocervical junction.
Publication TypeJournal Article
Year of Publication2017
AuthorsPiagkou, M., Manolakos O., Troupis T., Lazaridis N., Laios K., Samolis A., & Natsis K.
JournalActa Med Acad
Date Published2017 Nov
KeywordsAcromegaly, Adult, Humans, Male, Occipital Bone, Odontoid Process, Skull, Sphenoid Sinus

OBJECTIVE: This study adds important information regarding the morphological alterations caused by growth hormone hypersecretion in the skull and craniocervical junction (CCJ). A variably asymmetric skull due to acromegaly coexists with expansion of the paranasal sinuses and multiple Wormian bones.CASE REPORT: A pathologically asymmetric dry skull of a European male, aged 38 years at death, with cranial vault and skull base thickening is described. The extensive paranasal sinus pneumatization caused a generalized thinning of the bony walls. The sphenoid sinus expanded intraorbitally, leading to sella enlargement. The orbital asymmetry coexisted with platybasia and hypoplasia of the occipital condyles and the odontoid process. Facial skeleton elongation and mandibular overgrowth were combined with prognathism, malocclusion and overbite.CONCLUSION: Skull and CCJ alterations are of paramount importance when selecting the surgical approach, if surgery is indicated. Consecutively, detailed preoperative evaluation and planning is essential. During surgery, skilled and experienced neurosurgeons recognize anatomical landmarks, use neuronavigation and micro-instrumentation in order to remain on the midline avoiding any potential lethal vascular injury.

Alternate JournalActa Med Acad
PubMed ID29338280


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