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Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes.

TitleAsymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes.
Publication TypeJournal Article
Year of Publication2018
AuthorsGkaliagkousi, E., Gavriilaki E., Triantafyllou A., Nikolaidou B., Anyfanti P., Koletsos N., Vamvakis A., Dipla K., Lazaridis A., & Douma S.
JournalJ Clin Hypertens (Greenwich)
Volume20
Issue4
Pagination680-685
Date Published2018 04
ISSN1751-7176
KeywordsAdult, Arginine, Arterial Pressure, Biomarkers, Case-Control Studies, Essential Hypertension, Female, Humans, Hypertension, Male, Masked Hypertension, Middle Aged, Pulse Wave Analysis, Risk Factors, Vascular Stiffness, White Coat Hypertension
Abstract

Asymmetric dimethylarginine (ADMA) is a robust marker of endothelial dysfunction in patients with essential hypertension. We investigated ADMA levels and their association with vascular damage in untreated hypertension. We enrolled consecutive patients with untreated, recently diagnosed hypertension and age-matched normotensive individuals. 24-hour blood pressure, central hemodynamics, and arterial stiffness were recorded. A total of 311 individuals were studied: 165 with essential hypertension, 50 with masked hypertension, 25 with white-coat hypertension, and 71 normotensive individuals. ADMA levels significantly correlated with aortic augmentation index (AIx75) (r = .156, P = .006), aortic pulse pressure (r = .153, P = .007) and marginally with carotid-femoral pulse wave velocity (r = .110, P = .051), as well as with diastolic office BP. In the multivariate model, aortic AIx75 and age were the only statistically significant predictors of ADMA. This is the largest study to document an independent association between ADMA and aortic AIx75 but not with other indices of arterial stiffness.

DOI10.1111/jch.13237
Alternate JournalJ Clin Hypertens (Greenwich)
PubMed ID29447435

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