The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.


Primary malignant melanoma of the ascending colon.

TitlePrimary malignant melanoma of the ascending colon.
Publication TypeJournal Article
Year of Publication2018
AuthorsMiliaras, S., Ziogas I. A., Mylonas K. S., & Papadopoulos V. N.
JournalBMJ Case Rep
Date Published2018 Mar 09
KeywordsAbdomen, Abdominal Pain, Aftercare, Aged, Biomarkers, Tumor, Chemotherapy, Adjuvant, Colectomy, Colon, Ascending, Colonic Neoplasms, Diarrhea, Female, Humans, Laparotomy, MART-1 Antigen, Melanoma, Melanoma-Specific Antigens, Rare Diseases, S100 Proteins, Tomography, X-Ray Computed, Treatment Outcome, Vimentin

Malignant gastrointestinal melanoma is usually a metastatic lesion. We report the case of a 67-year-old female patient who presented with intermittent abdominal pain, fever, rigor and diarrhoea. CT scan of the abdomen revealed a large mass at the right iliac fossa with features concerning for intra-abdominal abscess. Exploratory laparotomy confirmed the preoperative diagnosis of abscess, and a right hemicolectomy was performed. Histopathological examination of the surgical specimen was indicative of malignant melanoma, and immunohistochemical examination showed positivity to S100 protein, Melan-A, HMB-45 and vimentin. A series of postoperative clinical, laboratory and imaging examinations revealed no suspicious lesions in the skin, eye, leptomeninges or other sites. Therefore, the diagnosis of primary colonic melanoma was confirmed. Only 36 additional cases of primary colonic melanoma have been reported to date. These rare neoplasms are challenging to diagnose and usually require a multidisciplinary treatment approach, including surgery, chemotherapy and possibly immunotherapy or radiotherapy.

Alternate JournalBMJ Case Rep
PubMed ID29523612


Secretariat of the School of Medicine


School of Medicine's presence in social networks
Follow Us or Connect with us.