The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study.
| Title | The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Kimiskidis, V. K., Papayiannopoulos S., Sotirakoglou K., Karakasis H., Katsarou Z., Kazis D. A., Papaliagkas V., Gatzonis S., Papadimitriou A., Hadjigeorgiou G., & Bostanjopoulou S. |
| Journal | Neurophysiol Clin |
| Volume | 48 |
| Issue | 4 |
| Pagination | 203-206 |
| Date Published | 2018 Sep |
| ISSN | 1769-7131 |
| Abstract | Mutations in the α-synuclein gene are a rare cause of Parkinson's disease. We investigated, by single-pulse TMS, the cortical excitability profile of nine α-synuclein patients in comparison with 24 idiopathic PD patients, subdivided into "akinetic" (n=17) and "tremor-dominant" (n=7) subgroups. The comparative assessment of rest motor threshold, active MEP and Silent Period Input/Output curves indicated that the cortical excitability of α-Synuclein patients is similar to patients with the "akinetic" form of PD. Both groups of patients exhibited differences in excitatory and inhibitory brain circuits from "tremor-dominant" patients indicating that varying clinical phenotypes are associated with differential profiles of corticospinal excitability. |
| DOI | 10.1016/j.neucli.2018.04.002 |
| Alternate Journal | Neurophysiol Clin |
| PubMed ID | 29729894 |
