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An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility.

TitleAn Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility.
Publication TypeJournal Article
Year of Publication2018
AuthorsChatzikyriakidou, A., Voulgari P. V., & Drosos A. A.
JournalArch Rheumatol
Volume33
Issue1
Pagination33-38
Date Published2018 Mar
ISSN2148-5046
Abstract

Objectives: This study aims to examine the following functional polymorphisms in rheumatoid arthritis (RA) susceptibility: (i) the 587C>T of kininogen gene, (ii) the 287 bp Alu repeat insertion of angiotensin converting enzyme gene, (iii) the 9 bp insertion of bradykinin receptor 2 gene, (iv) the -58T>C of bradykinin receptor 2 gene, and (v) the -699G>C of bradykinin receptor 1 gene.Patients and methods: The study included 136 RA patients (27 males; 109 females; mean age 60.8 years; range 39 to 75 years) and 149 ethnic matching controls (30 males, 119 females; mean age 56.2 years; range 35 to 78 years). Polymerase chain reaction coupled with restriction assay was performed for 587C>T, -58T>C, and -699G>C.Results: Rheumatoid arthritis patients and controls carried the wild type allele of 587C>T; therefore, produced the high molecular weight kininogen. No significant difference was observed in genotype or allele distribution of the studied functional polymorphisms between RA patients and controls.Conclusion: Kinin-kallikrein system related genes might not be major RA susceptibility loci.

DOI10.5606/ArchRheumatol.2018.6389
Alternate JournalArch Rheumatol
PubMed ID29901003
PubMed Central IDPMC5864169

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