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Primary Ewing sarcoma of the stomach--a newly described entity.

TitlePrimary Ewing sarcoma of the stomach--a newly described entity.
Publication TypeJournal Article
Year of Publication2009
AuthorsRafailidis, S., Ballas K., Psarras K., Pavlidis T., Symeonidis N., Marakis G., & Sakadamis A.
JournalEur Surg Res
Date Published2009
KeywordsAged, Antigens, CD, Cell Adhesion Molecules, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 22, Humans, Male, Oncogene Proteins, Fusion, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, Sarcoma, Ewing, Stomach Neoplasms, Translocation, Genetic

The Ewing sarcoma family of tumors (ESFT) includes classic Ewing sarcoma of the bone, extraosseous or soft tissue Ewing sarcoma, Askin tumors of the chest wall, and peripheral primitive neuroectodermal tumors of the bone and soft tissues. They share a common neural histogenesis, tumor genetics and biology. The genetic hallmark of the ESFT is the presence of t(11;22)(q24;q12), which creates the EWS/FLI1 fusion gene and results in the expression of a chimeric protein. Although Ewing tumors can occur at any age, the great majority are found in individuals less than 20 years of age. We herein report a case of gastric Ewing sarcoma in a 68-year-old male. This patient illustrates the second reported occurrence of primary Ewing sarcoma in the stomach and the first reported with the t(11;22)(q24;q12) gene translocation.

Alternate JournalEur Surg Res
PubMed ID18971581


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