The role of cytokines and adipocytokines in zoledronate-induced acute phase reaction in postmenopausal women with low bone mass.
Title | The role of cytokines and adipocytokines in zoledronate-induced acute phase reaction in postmenopausal women with low bone mass. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Anastasilakis, A. D., Polyzos S. A., Delaroudis S., Bisbinas I., Sakellariou G. T., Gkiomisi A., Papadopoulou E., Gerou S., & Makras P. |
Journal | Clin Endocrinol (Oxf) |
Volume | 77 |
Issue | 6 |
Pagination | 816-22 |
Date Published | 2012 Dec |
ISSN | 1365-2265 |
Keywords | Acute-Phase Reaction, Adipokines, Age Factors, Aged, Bone Density, Bone Density Conservation Agents, Cytokines, Diphosphonates, Female, Humans, Imidazoles, Insulin Resistance, Lymphocyte Count, Middle Aged, Nicotinamide Phosphoribosyltransferase, Osteoporosis, Postmenopausal, Postmenopause, Risk Factors, Zoledronic Acid |
Abstract | OBJECTIVE: Patients treated with intravenous zoledronate frequently experience an acute phase reaction (APR) characterized by flu-like symptoms and increased levels of inflammatory cytokines. We aimed to define the role of various cytokines/adipocytokines in zoledronate-induced APR and develop a prognostic model for its prediction. |
DOI | 10.1111/j.1365-2265.2012.04459.x |
Alternate Journal | Clin. Endocrinol. (Oxf) |
PubMed ID | 22676573 |