Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study.
| Title | Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Dalamaga, M., Polyzos S. A., Karmaniolas K., Chamberland J., Lekka A., Triantafilli M., Migdalis I., Papadavid E., & Mantzoros C. S. |
| Journal | Leuk Lymphoma |
| Volume | 57 |
| Issue | 3 |
| Pagination | 577-84 |
| Date Published | 2016 |
| ISSN | 1029-2403 |
| Keywords | Aged, alpha-2-HS-Glycoprotein, Biomarkers, Case-Control Studies, Female, Humans, Leptin, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Neoplasm Staging, Odds Ratio, Prognosis, Risk Factors |
| Abstract | There are limited data on fetuin-A, soluble leptin receptor (sOB-R) and free leptin index (FLI) in patients with chronic lymphocytic leukemia (CLL). The aim of this study was to compare circulating fetuin-A, sOB-R levels and FLI between 95 patients with CLL and 95 matched controls, as well as among different stages of CLL. Circulating fetuin-A was significantly lower in cases than controls (241.9 ± 99.2 vs. 288.8 ± 127.7 μg/mL; p = 0.005). Although circulating sOB-R levels were similar between groups, FLI was lower in cases than controls (0.45 ± 0.42 vs. 0.67 ± 0.57; p = 0.003). Furthermore, lower fetuin-A or FLI, but not sOB-R, were independently associated with CLL (p < 0.05), particularly among overweight/obese individuals. Fetuin-A, s-OB-R and FLI were similar between different stages of CLL severity, or between symptomatic and asymptomatic disease. In conclusion, circulating fetuin-A and FLI, but not sOB-R, were lower in patients with CLL than controls, a finding warranting further investigation. |
| DOI | 10.3109/10428194.2015.1075523 |
| Alternate Journal | Leuk. Lymphoma |
| PubMed ID | 26317877 |
