Hepatic precancerous lesions and small hepatocellular carcinoma.
Title | Hepatic precancerous lesions and small hepatocellular carcinoma. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Hytiroglou, P., Park Y. Nyun, Krinsky G., & Theise N. D. |
Journal | Gastroenterol Clin North Am |
Volume | 36 |
Issue | 4 |
Pagination | 867-87, vii |
Date Published | 2007 Dec |
ISSN | 0889-8553 |
Keywords | Carcinoma, Hepatocellular, Diagnosis, Differential, Humans, Liver, Liver Neoplasms, Precancerous Conditions, Severity of Illness Index |
Abstract | Precancerous lesions that may be detected in chronically diseased, usually cirrhotic livers, include: clusters of hepatocytes with atypia and increased proliferative rate (dysplastic foci) that usually represent an incidental finding in biopsy or resection specimens; and grossly evident lesions (dysplastic nodules) that may be detected on radiologic examination. There are two types of small hepatocellular carcinoma (HCC) (defined as HCC that measures less than 2 cm): early HCC, which is well-differentiated and has indistinct margins; and distinctly nodular small HCC, which is well- or moderately differentiated, and is usually surrounded by a fibrous capsule. Precise diagnosis of precancerous and early cancerous lesions by imaging methods is often difficult or impossible. Detection of a dysplastic lesion in a biopsy specimen is a marker of increased risk for HCC development, and warrants increased surveillance. High-grade dysplastic nodules and small HCCs should be treated by local ablation, surgical resection, or liver transplantation. |
DOI | 10.1016/j.gtc.2007.08.010 |
Alternate Journal | Gastroenterol. Clin. North Am. |
PubMed ID | 17996795 |