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Comparative immunohistochemical analysis of aurora-A and aurora-B expression in human glioblastomas. Associations with proliferative activity and clinicopathological features.

TitleComparative immunohistochemical analysis of aurora-A and aurora-B expression in human glioblastomas. Associations with proliferative activity and clinicopathological features.
Publication TypeJournal Article
Year of Publication2009
AuthorsSamaras, V., Stamatelli A., Samaras E., Arnaoutoglou C., Arnaoutoglou M., Stergiou I., Konstantopoulou P., Varsos V., Karameris A., & Barbatis C.
JournalPathol Res Pract
Volume205
Issue11
Pagination765-73
Date Published2009
ISSN1618-0631
KeywordsAdult, Aged, Aged, 80 and over, Analysis of Variance, Brain Neoplasms, Cell Proliferation, Cerebral Cortex, Combined Modality Therapy, Female, Glioblastoma, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Ki-67 Antigen, Male, Middle Aged, Protein-Serine-Threonine Kinases, Statistics, Nonparametric, Treatment Outcome
Abstract

In the present study, we carried out a comparative immunohistochemical analysis of aurora-A and aurora-B expression in 40 patients with primary glioblastomas, and attempted to identify any associations with Ki-67 index and the patients' clinical features. The impact of various treatment modalities and proliferative activity on patient outcome was also assessed. Immunohistochemistry was carried out using formalin-fixed and paraffin-embedded tissue sections. Aurora-A expression was higher in tumors with high Ki-67 expression (p=0.01) and was positively, though marginally, related to aurora-B expression (p=0.085). Aurora-B expression was not linked to Ki-67 expression (p=0.182). Lower aurora-A immunohistochemical expression, chemotherapy administration, and tumor localization in one lobe of the brain implied a greater probability of patient survival in univariate analysis (p=0.044, p=0.008, p=0.041, respectively). Ki-67 and aurora-B immunoreactivities were not associated with patient survival (p=0.918 and p=0.539, respectively). To our knowledge, for the first time, the association between aurora-A and aurora-B expression, the correlation of aurora-A with Ki-67 index, and the prognostic impact of aurora-A expression were assessed in glioblastomas. Although we addressed a prognostic connotation of aurora-A, we presume that aurora-A and aurora-B play a complicated role within glioblastomas. Further examinations of larger series are required, so that definite conclusions can be drawn.

DOI10.1016/j.prp.2009.06.011
Alternate JournalPathol. Res. Pract.
PubMed ID19616898

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