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Identification of high risk patients with hypertrophic cardiomyopathy in a northern Greek population.

TitleIdentification of high risk patients with hypertrophic cardiomyopathy in a northern Greek population.
Publication TypeJournal Article
Year of Publication2009
AuthorsEfthimiadis, G. K., Pliakos C., Pagourelias E. D., Parcharidou D. G., Giannakoulas G., Kamperidis V., Hadjimiltiades S., Karvounis C., Gavrielidis S., Styliadis I. H., & Parcharidis G.
JournalCardiovasc Ultrasound
Volume7
Pagination37
Date Published2009
ISSN1476-7120
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Cardiomyopathy, Hypertrophic, Echocardiography, Doppler, Electrocardiography, Ambulatory, Exercise Test, Female, Greece, Humans, Male, Middle Aged, Risk Factors, Statistics, Nonparametric
Abstract

BACKGROUND: The percentage of hypertrophic cardiomyopathy (HCM) patients who are in high risk for Sudden Death (SD) constitutes only a minority of all HCM population but the incidence of SD in this subset is high (at least 5% annually). The identification of this small but important proportion of high risk HCM patients has been the clue in the clinical evaluation of these patients.METHODS: Our study cohort consisted from 123 patients with HCM who are currently followed up in our Institution. Five clinical risk factors were assessed: a family history of premature SD, unexplained syncope, Non Sustained Ventricular Tachycardia (NSVT) on 24-h ECG monitoring, Abnormal Blood Pressure Response (ABPR) during upright exercise testing and Maximum left ventricular Wall Thickness (MWT) > or =30 mm. The purpose of our study was the identification of high risk HCM patients coming from Northern Greece.RESULTS: Fifteen patients (12.2%) of the whole cohort had MWT > or = 30 mm, 30 patients (24.4%) had an ABPR to exercise, 17 patients (13.8%) had episodes of NSVT in 24-h Holter monitoring, 17 patients (13.8%) suffered from syncope, and 8 patients (6.5%) had a positive family history of premature SD. Data analysis revealed that 74 patients (60.1%) had none risk factor. Twenty four patients (19.5%) had 1 risk factor, 17 patients (13.8%) had 2 risk factors, 4 patients (3.25%) had 3 risk factors, and 4 patients (3.25%) had 4 risk factors, while none patient had 5 risk factors. Twenty five patients (20.3%) had 2 or more risk factors.CONCLUSION: This study for the first time confirms that, although a 60% of patients with HCM coming from a regional Greek population are in low risk for SD, a substantial proportion (almost 20%) carries a high risk for SD justifying prophylactic therapy with amiodaron or ICD implantation.

DOI10.1186/1476-7120-7-37
Alternate JournalCardiovasc Ultrasound
PubMed ID19631000
PubMed Central IDPMC2724406

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