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Thrombotic risk factors and liver histologic lesions in non-alcoholic fatty liver disease.

TitleThrombotic risk factors and liver histologic lesions in non-alcoholic fatty liver disease.
Publication TypeJournal Article
Year of Publication2009
AuthorsPapatheodoridis, G. V., Chrysanthos N., Cholongitas E., Pavlou E., Apergis G., Tiniakos D. G., Andrioti E., Theodossiades G., & Archimandritis A. J.
JournalJ Hepatol
Volume51
Issue5
Pagination931-8
Date Published2009 Nov
ISSN1600-0641
KeywordsAdult, Antibodies, Anticardiolipin, Cohort Studies, Factor V, Fatty Liver, Female, Hepatitis B, Chronic, Hepatitis C, Chronic, Humans, Liver, Liver Cirrhosis, Male, Middle Aged, Prothrombin, Risk Factors, Thrombosis
Abstract

BACKGROUND/AIMS: The pathogenetic mechanisms of development of non-alcoholic steatohepatitis (NASH) and fibrosis are not clear, although thrombosis of small intrahepatic veins has been suggested to trigger liver tissue remodelling and thrombotic risk factors have been associated with more advanced fibrosis in chronic viral hepatitis (CVH). We evaluated the prevalence of thrombotic risk factors (RFs) in non-alcoholic fatty liver disease (NAFLD) and their possible association with fatty liver or NASH.METHODS: We included 60 patients with histologically documented NAFLD and a historical cohort of 90 patients with chronic hepatitis B (n=39) or C (n=51). Thrombophilic factors were evaluated on the day of the liver biopsy.RESULTS: One or more thrombotic RFs were detected in 37% of NAFLD patients, and >or= 2 RFs were detected in 12% of NAFLD patients, being less frequently present than in CVH patients (37% and 68%, respectively; P CONCLUSIONS: Thrombotic RFs are frequently present in patients with NAFLD and are associated with NASH and more advanced fibrosis. Such an association may have significant clinical implications, even though it is not clear yet whether it represents a primary or secondary phenomenon.

DOI10.1016/j.jhep.2009.06.023
Alternate JournalJ. Hepatol.
PubMed ID19726097

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