Effect of surgically guided axonal regrowth into a 3-way-conduit (isogeneic trifurcated aorta) on functional recovery after facial-nerve reconstruction: Experimental study in rats.
Title | Effect of surgically guided axonal regrowth into a 3-way-conduit (isogeneic trifurcated aorta) on functional recovery after facial-nerve reconstruction: Experimental study in rats. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Bendella, H., Rink S., Manthou M., Papamitsou T., Nakamura M., Angelov D. N., & Sarikcioglu L. |
Journal | Restor Neurol Neurosci |
Volume | 37 |
Issue | 2 |
Pagination | 181-196 |
Date Published | 2019 |
ISSN | 1878-3627 |
Keywords | Anastomosis, Surgical, Animals, Aorta, Abdominal, Axons, Facial Muscles, Facial Nerve, Facial Nerve Injuries, Female, Hypoglossal Nerve, Motor Activity, Nerve Regeneration, Neuromuscular Junction, Neurosurgical Procedures, Rats, Wistar, Reconstructive Surgical Procedures, Recovery of Function, Vibrissae |
Abstract | BACKGROUND: The "post-paralytic syndrome" after facial nerve reconstruction has been attributed to (i) malfunctioning axonal guidance at the fascicular (branches) level, (ii) collateral branching of the transected axons at the lesion site, and (iii) intensive intramuscular terminal sprouting of regenerating axons which causes poly-innervation of the neuromuscular junctions (NMJ). |
DOI | 10.3233/RNN-190899 |
Alternate Journal | Restor Neurol Neurosci |
PubMed ID | 31006701 |