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The effect of diabetes mellitus on in-hospital hyperglycemia, length of stay and survival in patients with brain tumor receiving dexamethasone: A descriptive and comparative analysis.

TitleThe effect of diabetes mellitus on in-hospital hyperglycemia, length of stay and survival in patients with brain tumor receiving dexamethasone: A descriptive and comparative analysis.
Publication TypeJournal Article
Year of Publication2019
AuthorsPantelidis, P., Tsitsopoulos P. P., Pappa E., Theologou E., Karanikolas N., Drosos C., & Tsonidis C.
JournalClin Neurol Neurosurg
Volume184
Pagination105450
Date Published2019 Sep
ISSN1872-6968
KeywordsAdult, Aged, Blood Glucose, Brain Neoplasms, Dexamethasone, Diabetes Complications, Diabetes Mellitus, Female, Humans, Hyperglycemia, Hypoglycemic Agents, Length of Stay, Male, Middle Aged
Abstract

OBJECTIVES: To perform a comparative analysis on the impact of Type 2 Diabetes Mellitus (DM) on in-hospital hyperglycemia, length of stay (LOS) and survival of patients suffering from brain tumor who receive dexamethasone.
PATIENTS AND METHODS: Patients with brain tumor hospitalized in a Neurosurgery department between 2011 and 2018, were studied. Data referring to medical history, clinical characteristics and in-hospital survival was collected and analyzed. Morning plasma glucose levels (PGL) were obtained for seven consecutive days after the start of dexamethasone.
RESULTS: Fifty-six patients were identified. Of them, 21 (37.5%) were diabetic. During dexamethasone administration, a difference in morning PGL values during different days was noted (p = 0.003). No difference in glucose levels among different glucocorticoid doses was seen. DM was associated with higher average PGL (aMPGL), calculated as the mean of morning PGL values for the last six days (p = 0.001) and with higher rates of persistent hyperglycemia (p = 0.002). The change of aMPGL from the morning PGL value of day one did not differ between the two cohorts (p = 0.729). DM neither affected LOS nor in-hospital survival (p = 0.745 & p = 0.438, respectively).
CONCLUSION: Although morning glucose values were higher in diabetic, compared to non-diabetic patients, their change from day one was similar between the two cohorts. LOS and in-hospital survival were not affected by DM.

DOI10.1016/j.clineuro.2019.105450
Alternate JournalClin Neurol Neurosurg
PubMed ID31376773

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