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Emergence of Klebsiella pneumoniae ST11 co-producing NDM-1 and OXA-48 carbapenemases in Greece.

TitleEmergence of Klebsiella pneumoniae ST11 co-producing NDM-1 and OXA-48 carbapenemases in Greece.
Publication TypeJournal Article
Year of Publication2019
AuthorsProtonotariou, E., Meletis G., Chatzopoulou F., Malousi A., Chatzidimitriou D., & Skoura L.
JournalJ Glob Antimicrob Resist
Volume19
Pagination81-82
Date Published2019 12
ISSN2213-7173
KeywordsAdult, Anti-Bacterial Agents, Bacterial Proteins, Base Composition, Base Sequence, beta-Lactamases, Drug Resistance, Multiple, Bacterial, Genes, Bacterial, Greece, Humans, Klebsiella pneumoniae, Male, Multilocus Sequence Typing, Plasmids, Whole Genome Sequencing
Abstract

OBJECTIVES: Klebsiella pneumoniae is a well-known pathogen frequently implicated in serious life-threatening nosocomial infections. Here we present a K. pneumoniae isolate (AHEPA1046) co-harbouring bla and bla isolated from a blood sample of an inpatient in Thessaloniki, Greece.
METHODS: Whole-genome sequencing (WGS) was performed using an Illumina MiniSeq Sequencing System. Multilocus sequence typing (MLST) was performed using a BLAST-based approach, and antimicrobial resistance genes and plasmid replicons were identified by ResFinder and PlasmidFinder, respectively. The Rapid Annotation using Subsystem Technology (RAST) v.2.0 server was used for genome annotation.
RESULTS: WGS analysis revealed the complete resistome of K. pneumoniae AHEPA1046. The strain harboured bla and bla together with 16 additional antimicrobial resistance genes and was resistant to carbapenems, aminoglycosides, quinolones, macrolides, tetracyclines, trimethoprim, fosfomycin and phenicols. Moreover, it was classified as ST11.
CONCLUSION: This is the first report of a K. pneumoniae clinical isolate from Greece co-producing NDM-1 and OXA-48 carbapenemases and is one of a few reported worldwide.

DOI10.1016/j.jgar.2019.08.020
Alternate JournalJ Glob Antimicrob Resist
PubMed ID31493526

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