The Efficacy of Stem Cells Secretome Application in Osteoarthritis: A Systematic Review of In Vivo Studies.
Title | The Efficacy of Stem Cells Secretome Application in Osteoarthritis: A Systematic Review of In Vivo Studies. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Bousnaki, M., Bakopoulou A., Kritis A., & Koidis P. |
Journal | Stem Cell Rev Rep |
Volume | 16 |
Issue | 6 |
Pagination | 1222-1241 |
Date Published | 2020 Dec |
ISSN | 2629-3277 |
Abstract | PURPOSE: Mesenchymal stem cells (MSCs) have appeared as a promising regenerative cell-based therapeutic, for degenerative conditions, such as OA, while the beneficial results from the application of MSCs have been attributed to the MSCs-derived secretome, which is the sum of cytoprotective factors produced by the MSCs. Aim of this study was to systematically review the literature in order to assess whether stem cell secretome (conditioned medium-CM, exosome-Exos or microvesicles-MV)(CM/Exos/MVs) treatment reduces inflammation and enhances cartilage regeneration in preclinical studies of experimental arthritis. |
DOI | 10.1007/s12015-020-09980-x |
Alternate Journal | Stem Cell Rev Rep |
PubMed ID | 32556944 |