Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus
Title | Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Tsetsos, F., Roumeliotis A., Tsekmekidou X., Alexouda S., Roumeliotis S., Theodoridis M., Thodis E., Panagoutsos S., Papanas N., Papazoglou D., Kotsa K., Yovos J. G., Maltezos E., Passadakis P., Paschou P., & Georgitsi M. |
Journal | Diab Vasc Dis Res |
Volume | 17 |
Issue | 6 |
Pagination | 1479164120970892 |
Date Published | 2020 Nov-Dec |
ISSN | 1752-8984 |
Abstract | BACKGROUND: Approximately one third of type 2 diabetes mellitus (T2DM) cases present with diabetic nephropathy (DN), the leading cause of end-stage renal disease. Inflammation plays an important role in T2DM disease and DN pathogenesis. NLRP3 inflammasomes are complexes that regulate interleukin-1B (IL-1B) and IL-18 secretion, both involved in inflammatory responses. Activation of NLRP3 is associated with DN onset and progression. Here, we explore whether DN is associated with variants in genes encoding key members of the NLRP3 inflammasome pathway. |
DOI | 10.1177/1479164120970892 |
Alternate Journal | Diab Vasc Dis Res |
PubMed ID | 33164551 |