Association of the Tau haplotype with Parkinson's disease in the Greek population.
| Title | Association of the Tau haplotype with Parkinson's disease in the Greek population. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Fidani, L., Kalinderi K., Bostantjopoulou S., Clarimón J., Goulas A., Katsarou Z., Hardy J., & Kotsis A. |
| Journal | Mov Disord |
| Volume | 21 |
| Issue | 7 |
| Pagination | 1036-9 |
| Date Published | 2006 Jul |
| ISSN | 0885-3185 |
| Keywords | Aged, Female, Gene Frequency, Genetics, Population, Genotype, Haplotypes, Humans, Male, Middle Aged, Parkinson Disease, Polymorphism, Genetic, Reference Values, tau Proteins |
| Abstract | We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03-2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. |
| DOI | 10.1002/mds.20864 |
| Alternate Journal | Mov Disord |
| PubMed ID | 16552760 |
| Grant List | G-0907 / / Parkinson's UK / United Kingdom G0701075 / / Medical Research Council / United Kingdom |
