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Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population.

TitleAssociation of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population.
Publication TypeJournal Article
Year of Publication2007
AuthorsFidani, L., Clarimon J., Goulas A., Hatzitolios A. I., Evans W., Tsirogianni E., Hardy J., & Kotsis A.
JournalEur J Neurol
Volume14
Issue7
Pagination745-9
Date Published2007 Jul
ISSN1468-1331
Keywords3',5'-Cyclic-AMP Phosphodiesterases, Aged, Aged, 80 and over, Alleles, Brain Ischemia, Cohort Studies, Cyclic Nucleotide Phosphodiesterases, Type 3, Cyclic Nucleotide Phosphodiesterases, Type 4, Female, Genetic Predisposition to Disease, Genotype, Greece, Haplotypes, Humans, Iceland, Male, Polymorphism, Single Nucleotide
Abstract

We have examined the association of phosphodiesterase 4D (PDE4D) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818-1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818-1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke.

DOI10.1111/j.1468-1331.2007.01767.x
Alternate JournalEur J Neurol
PubMed ID17594329
Grant ListG-0907 / / Parkinson's UK / United Kingdom
G0701075 / / Medical Research Council / United Kingdom
/ / Intramural NIH HHS / United States

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