Association of Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study.
Title | Association of Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Chatzikyriakidou, A., Chorti A., & Papavramidis T. |
Journal | In Vivo |
Volume | 33 |
Issue | 6 |
Pagination | 2281-2285 |
Date Published | 2019 Nov-Dec |
ISSN | 1791-7549 |
Keywords | Adult, Aged, Alleles, Biomarkers, Tumor, Carcinoma, Papillary, Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-1 Receptor-Associated Kinases, Male, Middle Aged, Odds Ratio, Pilot Projects, Polymorphism, Single Nucleotide, Thyroid Neoplasms, Young Adult |
Abstract | BACKGROUND/AIM: The incidence of thyroid cancer has increased predominantly due to an increase in papillary thyroid cancer (PTC). Alteration of toll-like receptor function has been reported to play a crucial role in carcinogenesis. The aim of the present study was to investigate predisposition to PTC associated with genetic markers of toll-like receptor and interleukin-1 receptor pathways involving nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-ĸB) stimulation. Specifically, the study focused on the following genes: interleukin-1 receptor-associated kinase 1 (IRAK1, rs3027898), NF-ĸB inhibitor alpha (NFKBIA, rs696), NF-ĸB subunit 1 (NFKB1, rs28362491), and microRNA-146a (miR-146a, rs2910164). |
DOI | 10.21873/invivo.11734 |
Alternate Journal | In Vivo |
PubMed ID | 31662568 |
PubMed Central ID | PMC6899100 |