The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.


Association of Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study.

TitleAssociation of Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study.
Publication TypeJournal Article
Year of Publication2019
AuthorsChatzikyriakidou, A., Chorti A., & Papavramidis T.
JournalIn Vivo
Date Published2019 Nov-Dec
KeywordsAdult, Aged, Alleles, Biomarkers, Tumor, Carcinoma, Papillary, Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-1 Receptor-Associated Kinases, Male, Middle Aged, Odds Ratio, Pilot Projects, Polymorphism, Single Nucleotide, Thyroid Neoplasms, Young Adult

BACKGROUND/AIM: The incidence of thyroid cancer has increased predominantly due to an increase in papillary thyroid cancer (PTC). Alteration of toll-like receptor function has been reported to play a crucial role in carcinogenesis. The aim of the present study was to investigate predisposition to PTC associated with genetic markers of toll-like receptor and interleukin-1 receptor pathways involving nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-ĸB) stimulation. Specifically, the study focused on the following genes: interleukin-1 receptor-associated kinase 1 (IRAK1, rs3027898), NF-ĸB inhibitor alpha (NFKBIA, rs696), NF-ĸB subunit 1 (NFKB1, rs28362491), and microRNA-146a (miR-146a, rs2910164).
PATIENTS AND METHODS: Forty-eight unrelated patients with papillary cancer restricted to the thyroid gland and 93 healthy volunteers were enrolled in the study.
RESULTS: A strong statistically significant difference was observed between patients with PTC and controls for IRAK1 rs3027898 variant. When the statistical analysis was replicated taking into account patient's sex, the rs3027898 A allele was revealed to be the risky variant in males.
CONCLUSION: Additional studies in larger groups of patients of various origins are needed to validate these preliminary findings.

Alternate JournalIn Vivo
PubMed ID31662568
PubMed Central IDPMC6899100


Secretariat of the School of Medicine


School of Medicine's presence in social networks
Follow Us or Connect with us.