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Association of Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study.

TitleAssociation of Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study.
Publication TypeJournal Article
Year of Publication2019
AuthorsChatzikyriakidou, A., Chorti A., & Papavramidis T.
JournalIn Vivo
Volume33
Issue6
Pagination2281-2285
Date Published2019 Nov-Dec
ISSN1791-7549
KeywordsAdult, Aged, Alleles, Biomarkers, Tumor, Carcinoma, Papillary, Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-1 Receptor-Associated Kinases, Male, Middle Aged, Odds Ratio, Pilot Projects, Polymorphism, Single Nucleotide, Thyroid Neoplasms, Young Adult
Abstract

BACKGROUND/AIM: The incidence of thyroid cancer has increased predominantly due to an increase in papillary thyroid cancer (PTC). Alteration of toll-like receptor function has been reported to play a crucial role in carcinogenesis. The aim of the present study was to investigate predisposition to PTC associated with genetic markers of toll-like receptor and interleukin-1 receptor pathways involving nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-ĸB) stimulation. Specifically, the study focused on the following genes: interleukin-1 receptor-associated kinase 1 (IRAK1, rs3027898), NF-ĸB inhibitor alpha (NFKBIA, rs696), NF-ĸB subunit 1 (NFKB1, rs28362491), and microRNA-146a (miR-146a, rs2910164).
PATIENTS AND METHODS: Forty-eight unrelated patients with papillary cancer restricted to the thyroid gland and 93 healthy volunteers were enrolled in the study.
RESULTS: A strong statistically significant difference was observed between patients with PTC and controls for IRAK1 rs3027898 variant. When the statistical analysis was replicated taking into account patient's sex, the rs3027898 A allele was revealed to be the risky variant in males.
CONCLUSION: Additional studies in larger groups of patients of various origins are needed to validate these preliminary findings.

DOI10.21873/invivo.11734
Alternate JournalIn Vivo
PubMed ID31662568
PubMed Central IDPMC6899100

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