Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis.
Title | Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Delivanoglou, N., Boziki M., Theotokis P., Kesidou E., Touloumi O., Dafi N., Nousiopoulou E., Lagoudaki R., Grigoriadis N., Charalampopoulos I., & Simeonidou C. |
Journal | J Neuroinflammation |
Volume | 17 |
Issue | 1 |
Pagination | 41 |
Date Published | 2020 Jan 29 |
ISSN | 1742-2094 |
Keywords | Animals, B-Lymphocytes, Brain, Encephalomyelitis, Autoimmune, Experimental, Female, Gene Expression Regulation, Immunohistochemistry, Mice, Mice, Inbred C57BL, Nerve Growth Factor, Receptor, trkA, Receptors, Nerve Growth Factor, Spinal Cord, T-Lymphocytes |
Abstract | BACKGROUND: Nerve growth factor (NGF) and its receptors, tropomyosin receptor kinase A (TrkA) and pan-neurotrophin receptor p75 (p75NTR), are known to play bidirectional roles between the immune and nervous system. There are only few studies with inconclusive results concerning the expression pattern and role of NGF, TrkA, and p75NTR (NGF system) under the neuroinflammatory conditions in multiple sclerosis (MS) and its mouse model, the experimental autoimmune encephalomyelitis (EAE). The aim of this study is to investigate the temporal expression in different cell types of NGF system in the central nervous system (CNS) during the EAE course. |
DOI | 10.1186/s12974-020-1708-9 |
Alternate Journal | J Neuroinflammation |
PubMed ID | 31996225 |
PubMed Central ID | PMC6990493 |