Elevated markers of thrombin generation and fibrinolysis in patients with active and quiescent ulcerative colitis.
Title | Elevated markers of thrombin generation and fibrinolysis in patients with active and quiescent ulcerative colitis. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Zezos, P., Papaioannou G., Nikolaidis N., Patsiaoura K., Vassiliadis T., Mpoumponaris A., Giouleme O., & Evgenidis N. |
Journal | Med Sci Monit |
Volume | 15 |
Issue | 11 |
Pagination | CR563-72 |
Date Published | 2009 Nov |
ISSN | 1643-3750 |
Keywords | Adolescent, Adult, Aged, Biological Markers, Case-Control Studies, Colitis, Ulcerative, Demography, Female, Fibrinolysis, Humans, Inflammation, Male, Middle Aged, Severity of Illness Index, Steroids, Thrombin, Young Adult |
Abstract | BACKGROUND: Prothrombotic abnormalities within the coagulation system, the presence of microvascular thrombi in intestinal mucosa, and the increased risk of thromboembolic complications in patients with Inflammatory bowel disease, suggest that a hypercoagulable state may be an important contributing factor in disease pathogenesis. The activation of the coagulation system in a cohort of ulcerative colitis patients was investigated.MATERIAL/METHODS: Markers of coagulation activation in blood (thrombin-antithrombin complex, TAT; prothrombin fragments 1 and 2, F1+2; and D-dimers) and markers of inflammation (erythrocyte sedimentation rate, ESR; C-reactive protein, CRP; and fibrinogen) were measured in 38 patients with active and 13 patients with long-standing quiescent ulcerative colitis. Disease activity was assessed by clinical, endoscopic, and histological criteria. The markers of coagulation activation were also measured in 28 healthy volunteers.RESULTS: There were no differences in TAT, F1+2, and D-dimer plasma levels between active and inactive ulcerative colitis. D-dimer and F1+2 levels were significantly higher in the active ulcerative colitis patients than in the healthy controls. Plasma levels of TAT, F1+2, and D-dimers did not differ between inactive ulcerative colitis patients and healthy controls. However, both active and inactive ulcerative colitis patients had significantly higher proportions of elevated (above-normal) values of coagulation markers than the healthy controls. Correlation analyses revealed strong correlation between ESR, fibrinogen, and D-dimers, which also correlated with the severity and extent of ulcerative colitis.CONCLUSIONS: A chronic low-grade activation of coagulation exists in ulcerative colitis, regardless of disease activity, and it might be implicated in disease pathogenesis. |
Alternate Journal | Med. Sci. Monit. |
PubMed ID | 19865055 |