Higher levels of s-RANKL and osteoprotegerin in children and adolescents with type 1 diabetes mellitus may indicate increased osteoclast signaling and predisposition to lower bone mass: a multivariate cross-sectional analysis.
Title | Higher levels of s-RANKL and osteoprotegerin in children and adolescents with type 1 diabetes mellitus may indicate increased osteoclast signaling and predisposition to lower bone mass: a multivariate cross-sectional analysis. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Tsentidis, C., Gourgiotis D., Kossiva L., Doulgeraki A., Marmarinos A., Galli-Tsinopoulou A., & Karavanaki K. |
Journal | Osteoporos Int |
Volume | 27 |
Issue | 4 |
Pagination | 1631-1643 |
Date Published | 2016 Apr |
ISSN | 1433-2965 |
Keywords | Absorptiometry, Photon, Adolescent, Biomarkers, Bone Density, Bone Diseases, Metabolic, Bone Remodeling, Case-Control Studies, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, Humans, Lumbar Vertebrae, Male, Osteoclasts, Osteoporosis, Osteoprotegerin, RANK Ligand, Signal Transduction |
Abstract | UNLABELLED: Simultaneous lower bone mineral density, metabolic bone markers, parathyroid hormone (PTH), magnesium, insulin-like growth factor 1 (IGF1), and higher levels of total soluble receptor activator of nuclear factor-kappa B ligand (s-RANKL), osteoprotegerin (OPG), and alkaline phosphatase (ALP) are indicative of lower osteoblast and increased osteoclast signaling in children and adolescents with type 1 diabetes mellitus, predisposing to adult osteopenia and osteoporosis. |
DOI | 10.1007/s00198-015-3422-5 |
Alternate Journal | Osteoporos Int |
PubMed ID | 26588909 |