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Transtympanic iontophoresis of gadopentetate dimeglumine: Preliminary results.

TitleTranstympanic iontophoresis of gadopentetate dimeglumine: Preliminary results.
Publication TypeJournal Article
Year of Publication2003
AuthorsChristodoulou, P., Doxas P. G., Papadakis C. E., Prassopoulos P., Maris T., & Helidonis E. S.
JournalOtolaryngol Head Neck Surg
Volume129
Issue4
Pagination408-13
Date Published2003 Oct
ISSN0194-5998
KeywordsAdministration, Topical, Animals, Contrast Media, Ear Diseases, Feasibility Studies, Gadolinium DTPA, Iontophoresis, Magnetic Resonance Imaging, Rabbits, Tympanic Membrane
Abstract

OBJECTIVE: We sought to demonstrate the feasibility of using iontophoresis to deliver pharmaceutical agents into the middle and inner ear for the treatment of middle and inner ear diseases, which is proved in this study by the successful iontophoresis of the ferromagnetic contrast agent gadopentetate dimeglumine. Study design and setting Eight rabbits were iontophoresed using gadopentetate dimeglumine solution 469 mg/mL. Then, all rabbits underwent magnetic resonance imaging for the detection of gadopentetate dimeglumine in the middle and inner ear structures. The study was conducted in the tertiary referral center the University Hospital of Crete.
RESULTS: The high signal intensity of the gadopentetate dimeglumine solution was demonstrated within the middle ear cavity and inner ear structures of all iontophoresed ears and in none of the noniontophoresed ones.
CONCLUSIONS: Transtympanic iontophoresis could be an effective method for the passage of pharmaceutical agents into the middle and inner ear for the treatment of middle and inner ear diseases.

DOI10.1016/s0194-5998(03)00713-7
Alternate JournalOtolaryngol Head Neck Surg
PubMed ID14574297

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