Transtympanic iontophoresis of gadopentetate dimeglumine: Preliminary results.
Title | Transtympanic iontophoresis of gadopentetate dimeglumine: Preliminary results. |
Publication Type | Journal Article |
Year of Publication | 2003 |
Authors | Christodoulou, P., Doxas P. G., Papadakis C. E., Prassopoulos P., Maris T., & Helidonis E. S. |
Journal | Otolaryngol Head Neck Surg |
Volume | 129 |
Issue | 4 |
Pagination | 408-13 |
Date Published | 2003 Oct |
ISSN | 0194-5998 |
Keywords | Administration, Topical, Animals, Contrast Media, Ear Diseases, Feasibility Studies, Gadolinium DTPA, Iontophoresis, Magnetic Resonance Imaging, Rabbits, Tympanic Membrane |
Abstract | OBJECTIVE: We sought to demonstrate the feasibility of using iontophoresis to deliver pharmaceutical agents into the middle and inner ear for the treatment of middle and inner ear diseases, which is proved in this study by the successful iontophoresis of the ferromagnetic contrast agent gadopentetate dimeglumine. Study design and setting Eight rabbits were iontophoresed using gadopentetate dimeglumine solution 469 mg/mL. Then, all rabbits underwent magnetic resonance imaging for the detection of gadopentetate dimeglumine in the middle and inner ear structures. The study was conducted in the tertiary referral center the University Hospital of Crete. |
DOI | 10.1016/s0194-5998(03)00713-7 |
Alternate Journal | Otolaryngol Head Neck Surg |
PubMed ID | 14574297 |