Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms.
| Title | Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Leszek, J., Trypka E., Koutsouraki E., Michmizos D., Yarla N. Sastry, Tarasov V. V., Ashraf G. Md, & Aliev G. |
| Journal | Curr Med Chem |
| Volume | 25 |
| Issue | 39 |
| Pagination | 5389-5394 |
| Date Published | 2018 |
| ISSN | 1875-533X |
| Keywords | Alzheimer Disease, Brain-Derived Neurotrophic Factor, Cytokines, Depression, Glucocorticoids, Humans, Inflammation, Pituitary-Adrenal System, Prefrontal Cortex, Receptors, Estrogen |
| Abstract | A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque. |
| DOI | 10.2174/0929867323666160902152829 |
| Alternate Journal | Curr Med Chem |
| PubMed ID | 27593962 |
