Association of Urinary Sodium Excretion with Vascular Damage: A Local Kidney Effect, Rather Than a Marker of Generalized Vascular Impairment.
Title | Association of Urinary Sodium Excretion with Vascular Damage: A Local Kidney Effect, Rather Than a Marker of Generalized Vascular Impairment. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Triantafyllou, A., Anyfanti P., Gkaliagkousi E., Zabulis X., Vamvakis A., Gkolias V., Petidis K., Aslanidis S., & Douma S. |
Journal | Int J Hypertens |
Volume | 2018 |
Pagination | 7620563 |
Date Published | 2018 |
ISSN | 2090-0384 |
Abstract | Evidence suggests that increased salt consumption induces blood pressure- (BP) mediated organ damage, yet it remains unclear whether it reflects a generalized micro- and macrovascular malfunction independent of BP. We studied 197 newly diagnosed and never-treated individuals with hypertension, intermediate hypertensive phenotypes, and normal BP, classified by use of 24-hour ambulatory BP monitoring. Sodium excretion and microalbuminuria were estimated in 24-hour urine samples, dermal capillary density was estimated from capillaroscopy, and arterial stiffness was estimated with pulse wave velocity (PWV) and augmentation index (AIx). Sodium excretion correlated with microalbuminuria (<0.001) and 24-hour and day- and nighttime systolic BP, but not with office blood pressure, arterial stiffness, or capillary density. In the multivariate analysis, the association with microalbuminuria was maintained (=0.007). In a population free from the long-standing effects of hypertension, increased salt intake appears to be associated with early signs of vascular kidney damage, rather than a diffuse micro- and macrovascular impairment. |
DOI | 10.1155/2018/7620563 |
Alternate Journal | Int J Hypertens |
PubMed ID | 30643643 |
PubMed Central ID | PMC6311280 |