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Endothelial Microvesicles Circulating in Peripheral and Coronary Circulation Are Associated With Central Blood Pressure in Coronary Artery Disease.

TitleEndothelial Microvesicles Circulating in Peripheral and Coronary Circulation Are Associated With Central Blood Pressure in Coronary Artery Disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsGkaliagkousi, E., Gavriilaki E., Vasileiadis I., Nikolaidou B., Yiannaki E., Lazaridis A., Triantafyllou A., Anyfanti P., Markala D., Zarifis I., & Douma S.
JournalAm J Hypertens
Volume32
Issue12
Pagination1199-1205
Date Published2019 11 15
ISSN1941-7225
KeywordsAcute Coronary Syndrome, Aged, Case-Control Studies, Cell-Derived Microparticles, Coronary Angiography, Coronary Artery Disease, Coronary Circulation, Endothelial Cells, Female, Flow Cytometry, Humans, Male, Middle Aged, Non-ST Elevated Myocardial Infarction, ST Elevation Myocardial Infarction
Abstract

BACKGROUND: Endothelial microvesicles (EMVs) have emerged as markers of endothelial injury. However, little is known about their levels in the coronary circulation of acute coronary syndrome (ACS) and stable coronary artery disease (CAD). We hypothesized that ACS patients exhibit a more pronounced increase of EMVs both in the peripheral and coronary circulation when compared with CAD. We also investigated possible associations of EMVs with markers preclinical target organ damage.METHODS: We enrolled consecutive eligible patients undergoing coronary angiography. Blood samples were collected from the stem of the left coronary artery and the femoral artery. ΕMVs were measured by a standardized flow cytometry protocol. Central systolic blood pressure (cSBP) was measured invasively and patients' history was recorded.RESULTS: CAD patients exhibited increased levels of EMVs compared with controls. When patients with ACS and stable CAD were compared, the former had significantly increased EMVs in both coronary and peripheral circulation. Importantly, both ACS and CAD patients exhibited increased levels of EMVs in the coronary circulation compared with periphery. In addition, EMVs were associated with cSBP.CONCLUSIONS: EMVs emerge as novel markers of ongoing underlying vascular damage, further augmenting the vicious cycle of inflammation and thrombosis mainly in ACS but also in stable CAD.

DOI10.1093/ajh/hpz116
Alternate JournalAm J Hypertens
PubMed ID31350539

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