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Exercise intensity-dependent immunomodulatory effects on encephalomyelitis.

TitleExercise intensity-dependent immunomodulatory effects on encephalomyelitis.
Publication TypeJournal Article
Year of Publication2019
AuthorsFainstein, N., Tyk R., Touloumi O., Lagoudaki R., Goldberg Y., Agranyoni O., Navon-Venezia S., Katz A., Grigoriadis N., Ben-Hur T., & Einstein O.
JournalAnn Clin Transl Neurol
Volume6
Issue9
Pagination1647-1658
Date Published2019 09
ISSN2328-9503
KeywordsAnimals, Chemokines, Cytokines, Encephalomyelitis, Autoimmune, Experimental, Gene Expression, Lymph Nodes, Lymphocyte Activation, Mice, Physical Conditioning, Animal, T-Lymphocytes
Abstract

BACKGROUND: Exercise training (ET) has beneficial effects on multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the intensity-dependent effects of ET on the systemic immune system in EAE remain undefined.OBJECTIVE: (1) To compare the systemic immune modulatory effects of moderate versus high-intensity ET protocols in protecting against development of EAE; (2) To investigate whether ET affects autoimmunity selectively, or causes general immunosuppression.METHODS: Healthy mice performed moderate or high-intensity treadmill running programs. Proteolipid protein (PLP)-induced transfer EAE was utilized to examine ET effects specifically on the systemic immune system. Lymph node (LN)-T cells from trained versus sedentary donor mice were transferred to naïve recipients and EAE severity was assessed, by clinical assessment and histopathological analysis. LN-T cells derived from donor trained versus sedentary PLP-immunized mice were analyzed in vitro for proliferation assays by flow cytometry analysis and cytokine and chemokine receptor gene expression using real-time PCR. T cell-dependent immune responses of trained versus sedentary mice to the nonautoantigen ovalbumin and susceptibility to Escherichia coli-induced acute peritonitis were examined.RESULTS: High-intensity training in healthy donor mice induced significantly greater inhibition than moderate-intensity training on proliferation and generation of encephalitogenic T cells in response to PLP-immunization, and on EAE severity upon their transfer into recipient mice. High-intensity training also inhibited LN-T cell proliferation in response to ovalbumin immunization. E. coli bacterial counts and dissemination were not affected by training.INTERPRETATION: High-intensity training induces superior effects in preventing autoimmunity in EAE, but does not alter immune responses to E. coli infection.

DOI10.1002/acn3.50859
Alternate JournalAnn Clin Transl Neurol
PubMed ID31368247
PubMed Central IDPMC6764499
Grant List / / The Judy and Sidney Swartz Fund for research in multiple sclerosis / International
/ / Chief Scientist Office of the Israeli Ministry of Health / International

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