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A randomized, single-blinded, vehicle-controlled study of a topical active blend in the treatment of androgenetic alopecia.

TitleA randomized, single-blinded, vehicle-controlled study of a topical active blend in the treatment of androgenetic alopecia.
Publication TypeJournal Article
Year of Publication2020
AuthorsKatoulis, A. C., Liakou A. I., Koumaki D., Vakirlis E., Tsantes A. G., Mortaki D., Bozi E., & Ioannides D.
JournalDermatol Ther
Volume33
Issue4
Paginatione13734
Date Published2020 Jul
ISSN1529-8019
Abstract

Αndrogenetic alopecia (AGA) is the most common hair disorder, affecting approximately 50% of men and women. A topical lotion that contains two patented formulas (Redensyl and Sepicontrol A5), has been introduced as an alternative approach to standard therapies for AGA. Forty-four patients with AGA were randomized either to apply the active lotion or the vehicle, twice daily for 24 weeks. Subjects were evaluated at 0, 12, and 24 weeks by clinical examination, photographic documentation, quality of life evaluation (DLQI), and trichogram (anagen-to-telogen ratio). Forty-one patients, 18 males and 23 females, completed the study. Among patients receiving active treatment (n = 26), 7.7% had great improvement, 73.1% had moderate improvement, and 19.2% remained stable. The median self-assessment score increased from 4 at baseline to 6 at 24 weeks (P < .001), while the DLQI improved from 4 to 3, respectively (P < .001). The median anagen-to-telogen ratio increased from 2.25 to 4.00 to 6.02 at weeks 0, 12, and 24, respectively. No significant adverse events were reported. This new topical active blend is effective in the treatment of AGA, with high degree of patients' satisfaction, improvement of quality of life, and an excellent safety profile. Thus, it may represent a useful alternative therapeutic approach for AGA.

DOI10.1111/dth.13734
Alternate JournalDermatol Ther
PubMed ID32473084

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