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Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study.

TitleComputerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study.
Publication TypeJournal Article
Year of Publication2020
AuthorsVilou, I., Bakirtzis C., Artemiadis A., Ioannidis P., Papadimitriou M., Konstantinopoulou E., Aretouli E., Messinis L., Nasios G., Dardiotis E., Kosmidis MH., & Grigoriadis N.
JournalJ Integr Neurosci
Date Published2020 Jun 30

In this explorative study, forty-seven patients with relapsing-remitting multiple sclerosis were randomized to a custom 6-week cognitive rehabilitation intervention (n = 23) using the BrainHQ web-based platform and to a control group condition (n = 24). Cognitive rehabilitation intervention consisted of two 40-minute sessions per week. All patients were tested with the Brief International Cognitive Assessment for Multiple Sclerosis battery, the Stroop Color-Word Test, and the trail making test, while the Beck Depression Inventory - Fast Screen questionnaire was used as a measure of mood and the cognitive reserve index as a measure of cognitive reserve. We used the reliable change index, to calculate clinically meaningful changes of performance, and to discriminate between responders and non-responders of this intervention. Statistically significant improvement of the group receiving treatment was observed mainly on measures of verbal and non-verbal episodic memory and, to a lesser extent, on reading speed, selective attention/response inhibition, and visual attention. Verbal memory and visual attention improvements remained significant after considering the corrected for multiple comparisons level of significance. According to reliable change index scores, 12/23 (52.2%) of patients in the intervention group presented meaningful improvement in at least one measure (Greek Verbal Learning Test: 26%, Brief Visuospatial Memory Test-Revised: 17.4%, Stroop-Words test: 13%). This explorative study provides evidence that, at least in the short term, cognitive rehabilitation may improve the cognitive performance of multiple sclerosis patients.

Alternate JournalJ Integr Neurosci
PubMed ID32706198
Grant List / US / United States / United States


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