Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.
Title | Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Panagopoulou, P., Skalkidou A., Marcotte E., Erdmann F., Ma X., Heck J. E., Auvinen A., Mueller B. A., Spector L. G., Roman E., Metayer C., Magnani C., Pombo-de-Oliveira M. S., Scheurer M. E., Mora A-M., Dockerty J. D., Hansen J., Kang A. Y., Wang R., Doody D. R., Kane E., Schüz J., Christodoulakis C., Ntzani E., & Petridou E. Th |
Corporate Authors | FRECCLE group, & NARECHEM-ST group |
Journal | Cancer Epidemiol |
Volume | 59 |
Pagination | 158-165 |
Date Published | 2019 04 |
ISSN | 1877-783X |
Keywords | Adolescent, Adult, Birth Weight, Case-Control Studies, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Leukemia, Myeloid, Acute, Logistic Models, Male, Parents, Registries, Risk, Surveys and Questionnaires, Young Adult |
Abstract | BACKGROUND: Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.AIM: To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.MATERIAL/METHODS: We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.RESULTS: Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.CONCLUSIONS: An increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children. |
DOI | 10.1016/j.canep.2019.01.022 |
Alternate Journal | Cancer Epidemiol |
PubMed ID | 30776582 |
PubMed Central ID | PMC7098424 |
Grant List | U58 DP000783 / DP / NCCDPHP CDC HHS / United States R21 CA175959 / CA / NCI NIH HHS / United States R13 ES024632 / ES / NIEHS NIH HHS / United States R03 ES021643 / ES / NIEHS NIH HHS / United States R13 ES021145 / ES / NIEHS NIH HHS / United States P01 ES018172 / ES / NIEHS NIH HHS / United States R01 CA175737 / CA / NCI NIH HHS / United States R01 ES009137 / ES / NIEHS NIH HHS / United States R13 ES022868 / ES / NIEHS NIH HHS / United States U13 ES026496 / ES / NIEHS NIH HHS / United States HHSN261201300012I / CA / NCI NIH HHS / United States R01 CA155461 / CA / NCI NIH HHS / United States R03 CA132172 / CA / NCI NIH HHS / United States |