The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.

Δημοσίευση

Does cognitive dysfunction correlate with neurofilament light polypeptide levels in the CSF of patients with multiple sclerosis?

TitleDoes cognitive dysfunction correlate with neurofilament light polypeptide levels in the CSF of patients with multiple sclerosis?
Publication TypeJournal Article
Year of Publication2019
AuthorsKalatha, T., Arnaoutoglou M., Koukoulidis T., Hatzifilippou E., Bouras E., Baloyannis S., & Koutsouraki E.
JournalJ Int Med Res
Volume47
Issue5
Pagination2187-2198
Date Published2019 May
ISSN1473-2300
KeywordsAdult, Biomarkers, Case-Control Studies, Cognitive Dysfunction, Female, Humans, Male, Multiple Sclerosis, Neurofilament Proteins, Prognosis
Abstract

OBJECTIVE: To investigate whether neurofilament light polypeptide (NfL) level in cerebrospinal fluid (CSF), currently a prognostic biomarker of neurodegeneration in patients with multiple sclerosis (MS), may be a potential biomarker of cognitive dysfunction in MS.METHODS: This observational case-control study included patients with MS. CSF levels of NfL were determined using enzyme-linked immunosorbent assay. Cognitive function was measured with the Brief International Cognitive Assessment for MS (BICAMS) battery and Paced Auditory Serial Addition Test (PASAT3), standardized to the Greek population.RESULTS: Of 39 patients enrolled (aged 42.7 ± 13.6 years), 36% were classified as cognitively impaired according to BICAMS z-scores (-0.34 ± 1.13). Relapsing MS was significantly better than progressive forms regarding BICAMS z-score (mean difference [MD] 1.39; 95% confidence interval [CI] 0.54, 2.24), Symbol Digit Modality Test score (MD 1.73; 95% CI 0.46, 3.0) and Greek Verbal Learning Test (MD 1.77; 95% CI 0.82, 2.72). An inversely proportional association between CSF NfL levels and BICAMS z-scores was found in progressive forms of MS (r = -0.944).CONCLUSIONS: This study provides preliminary evidence for an association between CSF NfL levels and cognition in progressive forms of MS, which requires validation in larger samples.

DOI10.1177/0300060519840550
Alternate JournalJ Int Med Res
PubMed ID30982375
PubMed Central IDPMC6567748

Contact

Secretariat of the School of Medicine
 

Connect

School of Medicine's presence in social networks
Follow Us or Connect with us.