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Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination.

TitleConnection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination.
Publication TypeJournal Article
Year of Publication2020
AuthorsZarogoulidis, P., Christakidis V., Petridis D., Sapalidis K., Kosmidis C., Vagionas A., Perdikouri E-I., Hohenforst-Schmidt W., Huang H., Petanidis S., Tsakiridis K., Baka S., Romanidis K., Zaric B., Kovacevic T., Stojsic V., Sarcev T., Bursac D., Kukic B., Boukovinas I., Tolis C., & Sardeli C.
JournalExpert Rev Respir Med
Date Published2020 Dec 04
ISSN1747-6356
Abstract

OBJECTIVES: Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed. Therefore, we need biomarkers or clusters of information that can provide early treatment prognosis.
METHODS: Biopsies were acquired from 471 patients-lung masses with CT-guided biopsy, convex probe transthorasic biopsy and EBUS-TBNA convex probe with 18G needles and 19G needles.
RESULTS: Standardized uptake value (SUV) measurement is associated with female, smoking status, hepatic metastasis, adenocarcinoma and programmed death-ligand 1 (PD-L1). In specific we expect that SUV ≥ 7 is associated with PD-L1 ≥ 50.
CONCLUSIONS: Lung masses indifferent of size that have SUV ≥ 7 will also have PD-L1 expression ≥ 50. Also, it is likely that these patients will be female with intense smoking habit and hepar or multiple metastasis.

DOI10.1080/17476348.2021.1859373
Alternate JournalExpert Rev Respir Med
PubMed ID33275458

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