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A patient with chronic hepatitis B and regression of fibrosis during treatment.

TitleA patient with chronic hepatitis B and regression of fibrosis during treatment.
Publication TypeJournal Article
Year of Publication2010
AuthorsChang, C. Y., Martin P., Fotiadu A., & Hytiroglou P.
JournalSemin Liver Dis
Date Published2010 Aug
KeywordsAntiviral Agents, Biopsy, DNA, Viral, Drug Administration Schedule, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Hepatitis B, Chronic, Humans, Liver Cirrhosis, Male, Middle Aged, Time Factors, Treatment Outcome, Viral Load

We present a patient with HBeAg-negative chronic hepatitis B, in whom significant regression of hepatic fibrosis was achieved after a lengthy antiviral treatment. A liver biopsy specimen obtained at initiation of treatment showed chronic hepatitis B with mild activity (histologic activity index: 7) and marked fibrosis (stage 4, in a scale of 0 to 6). A second biopsy specimen, obtained 10 years later, demonstrated almost complete resolution of necroinflammatory activity and fibrosis. One year after the second biopsy, seroconversion from HBsAg positive to anti-HBs positive status was achieved, and antiviral treatment was discontinued. This case is illustrative of the significant histologic improvement that can be accomplished in chronic hepatitis B when viral activity is suppressed long term. Lengthy antiviral treatment can achieve resorption of excess fibrous tissue, even in patients with marked fibrosis.

Alternate JournalSemin. Liver Dis.
PubMed ID20665381


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