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Exercise capacity in idiopathic pulmonary fibrosis: the effect of pulmonary hypertension.

TitleExercise capacity in idiopathic pulmonary fibrosis: the effect of pulmonary hypertension.
Publication TypeJournal Article
Year of Publication2011
AuthorsBoutou, A. K., Pitsiou G. G., Trigonis I., Papakosta D., Kontou P. K., Chavouzis N., Nakou C., Argyropoulou P., Wasserman K., & Stanopoulos I.
Date Published2011 Apr
KeywordsAdult, Anaerobic Threshold, Cardiac Catheterization, Exercise, Exercise Test, Female, Heart Rate, Humans, Hypertension, Pulmonary, Idiopathic Pulmonary Fibrosis, Male, Middle Aged, Oxygen Consumption, Physical Endurance, Retrospective Studies

BACKGROUND AND OBJECTIVE: Increased pulmonary arterial pressure (PAP) usually coexists with impaired lung function in IPF. Data on the effect of pulmonary hypertension (PH) on cardiopulmonary responses during exercise in IPF patients is very limited. We sought to investigate the impact of PH on exercise capacity and the correlation between systolic PAP (sPAP) and pulmonary function testing, as well as cardiopulmonary exercise parameters, in patients with IPF and PH.METHODS: Eighty-one consecutive patients with IPF, who were evaluated over a 6-year period, were retrospectively studied. Patients underwent pulmonary function testing, Doppler echocardiography and maximal cardiopulmonary exercise testing. PH was defined as sPAP > 35 mm Hg.RESULTS: PH was diagnosed in 57% of the patients. Categorization of patients according to severity of PH indicated a significant reduction in maximum work rate, peak O(2) uptake, anaerobic threshold and peak O(2) pulse in those with sPAP > 50 mm Hg. In IPF patients with PH, estimated sPAP correlated with peak O(2) uptake, anaerobic threshold, peak O(2) pulse and end-tidal CO(2) at anaerobic threshold, while the strongest correlation was between sPAP and ventilatory equivalent for CO(2) at anaerobic threshold (r = 0.611, P < 0.001). There were no differences in pulmonary function or exercise parameters indicative of lung volume reduction, across the patient categories, and none of these parameters correlated with sPAP.CONCLUSIONS: PH has a negative impact on exercise capacity in IPF patients. In IPF patients with PH, resting sPAP correlated with exercise parameters indicative of gas exchange and circulatory impairment, but not with defective lung mechanics.

Alternate JournalRespirology
PubMed ID21122030


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