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Neuromotor outcomes in infants with bronchopulmonary dysplasia.

TitleNeuromotor outcomes in infants with bronchopulmonary dysplasia.
Publication TypeJournal Article
Year of Publication2011
AuthorsKaragianni, P., Tsakalidis C., Kyriakidou M., Mitsiakos G., Chatziioanidis H., Porpodi M., Evangeliou A., & Nikolaides N.
JournalPediatr Neurol
Volume44
Issue1
Pagination40-6
Date Published2011 Jan
ISSN1873-5150
KeywordsApgar Score, Bronchopulmonary Dysplasia, Child Development, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Infant, Very Low Birth Weight, Length of Stay, Leukomalacia, Periventricular, Male, Nervous System Diseases, Neurologic Examination, Prospective Studies, Risk Factors
Abstract

We examine the neuromotor outcomes of preterm infants with bronchopulmonary dysplasia. Two hundred and nineteen infants (gestational age, ≤ 32 weeks; birth weight, ≤ 1500 g) were studied. Neuromotor development was assessed using the Hammersmith Infant Neurological Examination. All potential risk factors associated with neuromotor scores (P < 0.015) were included in the generalized linear model (multiple linear regression) to determine if bronchopulmonary dysplasia had an independent relationship with neuromotor scores. Infants with severe bronchopulmonary dysplasia had lower global scores at ages 6 and 12 months. After adjustment for confounding factors, scores of infants with severe bronchopulmonary dysplasia were reduced by 13.2 units, whereas scores for those with periventricular leukomalacia were reduced by 11.1 units, at age 6 months. At age 12 months, scores for those with periventricular leukomalacia were reduced by 11.9 units. Duration of hospital stay reduced scores by 0.1 for each additional day increase in hospital. Bronchopulmonary dysplasia constitutes a major cause of poor neuromotor outcomes at age 6 months, but improvements in motor outcomes occur over time.

DOI10.1016/j.pediatrneurol.2010.07.008
Alternate JournalPediatr Neurol
PubMed ID21147386

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