Alterations of bone mineral metabolism of children with different cell lineage types of acute lymphoblastic leukaemia under chemotherapy.
Title | Alterations of bone mineral metabolism of children with different cell lineage types of acute lymphoblastic leukaemia under chemotherapy. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Tragiannidis, A., Dokos C., Sidi V., Papageorgiou T., Koliouskas D., Karamouzis M., Papastergiou C., Tsitouridis I., Katzos G., Rousso I., & Athanassiadou-Piperopoulou F. |
Journal | Hippokratia |
Volume | 15 |
Issue | 1 |
Pagination | 43-7 |
Date Published | 2011 Jan |
ISSN | 1790-8019 |
Abstract | BACKGROUND: Children with haematological malignancies such as acute lymphoblastic leukaemia (ALL) may have alteration of bone mineral metabolism therefore increased risk for osteopenia and osteoporosis.PATIENTS AND METHODS: The purpose of this study was to examine the alterations of bone mineral metabolism in two groups of children (n=42) according to immunophenotyping (B-cell type, T-cell type) both quantitative (bone mineral density z-scores) and qualitative (serum osteocalcin - OC and carboxyl-terminal telopeptide of human type I collagen - ICTP) during diagnosis (T=0), after the intensified chemotherapy period (T=0.5) and the consolidation period (T=1).RESULTS: According to our results 15 patients had osteopenia and 1 child developed osteoporosis at T=0.5 and 13 patients had osteopenia at T=1. Mean BMD z-score was significantly decreased in both groups during chemotherapy and especially statistically significant decline of T-cell type ALL group compared with B-cell type ALL patients. OC mean level remains in low levels for both groups reaching in plateau during chemotherapy and ICTP level was increased in T-cell type ALL group of patients compared with B-cell type in both periods of chemotherapy.CONCLUSIONS: It seems that not only the combination of chemotherapeutic agents but also the cell lineage of ALL are important parameters of altering bone mineral metabolism. |
Alternate Journal | Hippokratia |
PubMed ID | 21607035 |
PubMed Central ID | PMC3093144 |