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Serum pattern of circulating soluble receptor of leptin throughout the menstrual cycle.

TitleSerum pattern of circulating soluble receptor of leptin throughout the menstrual cycle.
Publication TypeJournal Article
Year of Publication2011
AuthorsGianisslis, G., Simopoulou M., Vakalopoulos I., Zeginiadou T., Tripsianis G., Ktenidou-Kartali S., Nikolettos N., & Asimakopoulos B.
JournalMinerva Ginecol
Volume63
Issue4
Pagination339-42
Date Published2011 Aug
ISSN0026-4784
KeywordsAdult, Female, Humans, Menstrual Cycle, Receptors, Leptin, Young Adult
Abstract

AIM: The aim of the study was to investigate the pattern of circulating soluble receptor of leptin (sLeptinR) during the menstrual cycle and the association of sLeptinR to leptin, sex hormones and gonadotropins.METHODS: Fasting blood samples were collected on alternate days throughout a full cycle from fifteen healthy volunteers. Immunoenzymatic assays were employed to record the relevant levels.RESULTS: sLeptinR concentrations throughout the cycle were found to vary negligibly. No significant correlations between sLeptinR and leptin, gonadotropins or progesterone, were established. During the follicular phase, subjects presenting with higher estradiol levels tended to have higher sLeptinR concentrations.CONCLUSION: The little variation of sLeptinR concentrations during the menstrual cycle indicates that the rise of leptin during the luteal phase implies an increase of its bioactivity.

Alternate JournalMinerva Ginecol
PubMed ID21747342

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