Increase in interleukin-6 levels is related to depressive phenomena in the acute (relapsing) phase of multiple sclerosis.
| Title | Increase in interleukin-6 levels is related to depressive phenomena in the acute (relapsing) phase of multiple sclerosis. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Koutsouraki, E., Hatzifilipou E., Michmizos D., Cotsavasiloglou C., Costa V., & Baloyannis S. |
| Journal | J Neuropsychiatry Clin Neurosci |
| Volume | 23 |
| Issue | 4 |
| Pagination | 442-8 |
| Date Published | 2011 Fall |
| ISSN | 1545-7222 |
| Keywords | Adult, Depression, Disability Evaluation, Female, Humans, Interleukin-6, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Young Adult |
| Abstract | The aim of the present study was to investigate the possible connection between interleukin-6, the acute phase (relapse) of multiple sclerosis (MS), and depression. The authors determined and statistically evaluated the levels of interleukin-6 and its soluble receptor in the serum of 28 MS patients in relapsing, 14 MS patients in remission, and 20 control subjects, as well as the presence of depression among these individuals. The results of our study indicate that depression is not only very common during relapses of MS, but also that the levels of IL-6 increase during the acute phase of the disease, especially when depression is detected. |
| DOI | 10.1176/appi.neuropsych.23.4.442 |
| Alternate Journal | J Neuropsychiatry Clin Neurosci |
| PubMed ID | 22231316 |
