Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model.
Title | Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Lalountas, M., Ballas K. D., Michalakis A., Psarras K., Asteriou C., Giakoustidis D. E., Nikolaidou C., Venizelos I., Pavlidis T. E., & Sakantamis A. K. |
Journal | Br J Surg |
Volume | 99 |
Issue | 3 |
Pagination | 423-9 |
Date Published | 2012 Mar |
ISSN | 1365-2168 |
Keywords | Animals, Biocompatible Materials, Carboxymethylcellulose Sodium, Fibrosis, Heptanoic Acids, Hyaluronic Acid, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Pyrroles, Random Allocation, Rats, Rats, Wistar, Tissue Adhesions |
Abstract | BACKGROUND: Intraperitoneal adhesions are a common problem in abdominal surgery. The aim of this study was to compare the effectiveness of Statofilm, a novel antiadhesive film based on cross-linked carboxymethylcellulose and atorvastatin, with that of sodium hyaluronate-carboxymethylcellulose (Seprafilm(®)) in the prevention of postoperative intraperitoneal adhesions in rats.METHODS: One hundred male Wistar rats underwent a laparotomy and adhesions were induced by caecal abrasion. The animals were allocated to five groups: a control group with no adhesion barrier, Seprafilm(®) group, placebo group with a film containing carboxymethylcellulose without atorvastatin, and low- and high-dose groups with films containing carboxymethylcellulose and atorvastatin 0·125 and 1 mg per kg bodyweight respectively. Adhesions were classified by two independent surgeons 2 weeks after surgery. Caecal biopsies were obtained for histological evaluation of fibrosis, inflammation and vascular proliferation.RESULTS: All antiadhesive film groups (Seprafilm(®), placebo, low-dose and high-dose) had statistically significant adhesion reduction compared with the control group (P < 0·001, P = 0·015, P < 0·001 and P < 0·001 respectively). The low-dose Statofilm was superior to Seprafilm(®) in terms of adhesion prevention (P = 0·001). Adhesions were present in three-quarters of rats in the Seprafilm(®) group, but only one-quarter in the low-dose Statofilm group.CONCLUSION: The data suggest that the newly developed adhesion barrier Statofilm has better results than Seprafilm(®) in preventing postoperative adhesions in rats. A low-dose atorvastatin-containing film, such as Statofilm, could be evaluated for future clinical application. |
DOI | 10.1002/bjs.7817 |
Alternate Journal | Br J Surg |
PubMed ID | 22246725 |