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Anemia is associated with mortality following endovascular repair of abdominal aortic aneurysm.

TitleAnemia is associated with mortality following endovascular repair of abdominal aortic aneurysm.
Publication TypeJournal Article
Year of Publication2012
AuthorsSaratzis, A., Melas N., Hunter J. P., Dixon H., Nightingale P., Kiskinis D., Saratzis N., & Kitas G. D.
JournalVasc Endovascular Surg
Volume46
Issue3
Pagination223-8
Date Published2012 Apr
ISSN1938-9116
KeywordsAged, Anemia, Aortic Aneurysm, Abdominal, Biological Markers, Blood Vessel Prosthesis Implantation, C-Reactive Protein, Comorbidity, Endovascular Procedures, Female, Great Britain, Humans, Inflammation Mediators, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Registries, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Up-Regulation
Abstract

AIM: The aim of this study was to compare midterm mortality between anemic and nonanemic patients undergoing endovascular repair of abdominal aortic aneurysm and to assess a correlation with markers of inflammation.METHODS: Anemia was defined as hemoglobin <13 (men) and <12 g/dL (women). The impact of anemia and inflammatory markers on mortality was assessed using Kaplan-Meier curves and Cox regression.RESULTS: A total of 224 patients (12 females [5.36%]; age: 69.73 ± 8.72 years) were included; 102 (45.53%) were anemic. Median follow-up was 17 months (interquartile range: 7-25 months). Nine patients died (1.79%; 8 anemic vs 1 nonanemic). Survival was lower for patients with anemia (log-rank, P = .01). White blood cell count and C-reactive protein (CRP) differed significantly (P < .001 and P = .01). Anemia and CRP were associated with decreased survival (Cox regression, P = .01, hazard ratio [HR]: 0.35, 95% confidence interval: 0.14-0.84 and P = .002, HR: 1.18, 95% CI: 1.06-1.31).CONCLUSION: Patients with anemia had decreased survival over the midterm; inflammatory markers were higher among this group.

DOI10.1177/1538574412442251
Alternate JournalVasc Endovascular Surg
PubMed ID22492108

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