The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.

Δημοσίευση

Copper levels in patients with hematological malignancies.

TitleCopper levels in patients with hematological malignancies.
Publication TypeJournal Article
Year of Publication2012
AuthorsKaiafa, G. D., Saouli Z., Diamantidis M. D., Kontoninas Z., Voulgaridou V., Raptaki M., Arampatzi S., Chatzidimitriou M., & Perifanis V.
JournalEur J Intern Med
Volume23
Issue8
Pagination738-41
Date Published2012 Dec
ISSN1879-0828
KeywordsAcute Disease, Adolescent, Adult, Aged, Antigens, CD38, Chronic Disease, Copper, Disease Progression, Female, Hematologic Neoplasms, Humans, Immunoglobulin Variable Region, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Lymphoma, Male, Membrane Glycoproteins, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Recurrence, Remission Induction, Tumor Markers, Biological, Young Adult, ZAP-70 Protein-Tyrosine Kinase
Abstract

BACKGROUND: Copper levels are elevated in cancer patients compared to normal subjects. However, few studies have investigated the relationship between copper and hematological malignancies.METHODS: 84 patients with hematological diseases were studied, along with 50 healthy individuals. Copper was measured by flame atomic absorption spectrometry. The patients were classified to 2 homogeneous groups, acute and chronic hematological neoplasms, respectively. For the patients with acute hematological malignancies, relapse and remission were investigated in relation to serum copper levels. For chronic hematological neoplasms, serum copper was connected either with stable or progressive disease. Zeta-chain-associated protein kinase 70 (ZAP70) and CD38 expression, along with the unmutated VH immunoglobulin genes (IgVH) status were also determined for the 22 chronic lymphocytic leukemia (CLL) patients.RESULTS: 54 patients with relapse or progressive disease had elevated copper levels (mean value 1.8 mg/l), whereas 30 patients either in remission or in stable disease had normal copper levels (mean value 1.01 mg/l) (normal range 0.8-1.3mg/l).CONCLUSION: Hence, our study indicates that serum elevated copper levels are associated with hematological malignancies either in relapse or in disease progression, whereas normal copper levels are linked with hematological neoplasms in remission or in stable disease. Furthermore, we report for the first time an association between high serum copper levels and several adverse prognostic markers in CLL, such as increased expression of ZAP70 and CD38, along with elevated percentage of unmutated IgVH.

DOI10.1016/j.ejim.2012.07.009
Alternate JournalEur. J. Intern. Med.
PubMed ID22920946

Contact

Secretariat of the School of Medicine
 

Connect

School of Medicine's presence in social networks
Follow Us or Connect with us.